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MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 76-year-old man with a 17-year history of type 2 diabetes mellitus attended for his annual review. Comparison of his retinal screening report with the previous year's report showed that his visual acuity was unchanged at 6/9 in both eyes. The previous year's right eye retinal image had been reported as 'pre-proliferative retinopathy', whereas this year's was reported as 'pre-proliferative retinopathy with maculopathy'.
What is the most appropriate next step?
A) routine re-screen in 6 months
B) urgent re-screen within 2 weeks
C) routine re-screen in 12 months
D) routine referral to an ophthalmologist
E) urgent referral to an ophthalmologist within 2 weeks
2. A 33-year-old man was referred to the diabetes clinic with an 8-month history of weight loss and polydipsia. Two months previously his general practitioner had found a high fasting plasma glucose concentration of 17.5 mmol/L (3.0-6.0) and a haemoglobin A1c of 116 mmol/mol (20-42). The patient was taking metformin 1 g twice daily. He reported in the diabetes clinic that his home capillary blood glucose concentrations persisted to be high, ranging between 15-24 mmol/L.
On examination, his body mass index was 23 kg/m2 (18-25).
His blood tests were repeated in the diabetes clinic and he was treated with a basal bolus insulin regimen. Urinalysis was negative for ketones.
Investigations (in diabetes clinic):
haemoglobin A1c110 mmol/mol (20-42)
serum C-peptide200 pmol/L (180-360)
anti-glutamic acid decarboxylase (GAD)
antibodies69 IU/mL (<10)
anti-IA2 antibodiesnegative
What is the most likely diagnosis?
A) haemochromatosis
B) mitochondrial diabetes mellitus
C) latent autoimmune diabetes in adults
D) type 1 diabetes mellitus
E) maturity-onset diabetes of the young
3. A 23-year-old man presented with a history of discomfort with his gender for as long as he could remember. He believed he was transsexual.
What element of further history would most strongly support his self-diagnosis?
A) conscious and absolute rejection of his sexual orientation as socially unacceptable
B) the presence of gender somatic delusions that emerge and strengthen with time
C) seeking medical rationalisation for sexuality through genital surgery
D) a long-standing intense wish to make his body conform to that of the preferred gender
E) sexual excitement by cross-dressing
4. A 24-year-old woman was referred with an 18-month history of worsening hirsutism, primarily on her face, but also new hair growth on her chest. She was shaving weekly. She had always been overweight, but had recently gained 5 kg and her body mass index was 31 kg/m2 (18-25). Her periods were regular.
What is the most relevant next investigation?
A) overnight dexamethasone suppression test (after 1 mg dexamethasone)
B) plasma thyroid-stimulating hormone
C) serum testosterone
D) serum 17-hydroxyprogesterone
E) serum dehydroepiandrosterone
5. A 46-year-old man of European descent was reviewed in the diabetes clinic. He had type 2 diabetes mellitus, which had been diagnosed 6 months previously. He had been symptom free and was a non-smoker but had a family history of cardiovascular disease. He exercised regularly and had managed to lose 8 kg.
On examination, his blood pressure was 148/76 mmHg, his weight was 76 kg and his body mass index was 24 kg/m2 (18-25).
Investigations:
urinary albumin:creatinine ratio0.6 mg/mmol (<2.5)
serum cholesterol5.6 mmol/L (<5.2)
serum HDL cholesterol0.90 mmol/L (>1.55)
fasting serum triglycerides2.20 mmol/L (0.45-1.69)
According to NICE guidelines (CG181, July 2014), what is the most appropriate management of his lipid profile?
A) observe and repeat lipid profile in a few months
B) start nicotinic acid
C) start a statin
D) assess cardiovascular risk using UKPDS risk engine
E) start a fibrate
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: C | Question # 3 Answer: D | Question # 4 Answer: C | Question # 5 Answer: C |
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